| Title | Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Reichard KK, Zhang QY, Sanchez L, Hozier J, Viswanatha D, Foucar K |
| Journal | Am J Hematol |
| Volume | 81 |
| Issue | 3 |
| Pagination | 178 - 85 |
| Date Published | Mar |
| Accession Number | 16493618 |
| Keywords | *Bone Marrow Transplantation, *Living Donors, *Transplantation Chimera, Adult, Chromosome Aberrations, Chromosomes, Human / genetics, Female, Humans, In Situ Hybridization, Fluorescence / methods, Karyotyping, Leukemia, Myelocytic, Acute / *etiology / genetics / pathology, Leukemia, T-Cell, Acute / complications / genetics / pathology / *therapy, Male, Neoplasms, Second Primary / *etiology / genetics / pathology, Transplantation, Homologous |
| Abstract | We report a case of donor-derived acute myeloid leukemia (AML) occurring in a 33-year-old man after allogeneic bone marrow transplantation (BMT) for precursor T-cell acute lymphoblastic -leukemia (T-ALL). The cells for BMT were from his human leukocyte antigen (HLA)-matched sister. Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin. Donor-cell leukemia (DCL) after allogeneic BMT is a rare, yet well-documented, event. Our report presents clinicopathologic information about a case of DCL and a review of the recent literature. |
| Notify Library Reference ID | 1306 |
