Title | Infections Transmitted by Transplantation |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Morris MI, Fischer SA, Ison MG |
Journal | Infectious Disease Clinics of North America |
Volume | 24 |
Issue | 2 |
Pagination | 497 - + |
Date Published | Jun |
Type of Article | Article |
ISSN | 0891-5520 |
Accession Number | ISI:000278466600013 |
Keywords | blood-donors, bone-marrow-transplantation, chagas-disease, Donor screening, Donor-derived infection, hepatitis-c virus, human-immunodeficiency-virus, liver-transplantation, Organ transplant, solid-organ transplantation, transmission, trypanosoma-cruzi, united-states, us, west-nile-virus |
Abstract | Infections are frequently transmitted through solid-organ and, to a lesser extent, stem cell transplantation. There are 2 major types of donor-derived infections that are transmitted: those that would be expected secondary to donor and recipient screening (ie, transmission of cytomegalovirus, Epstein-Barr virus, or toxoplasmosis from a seropositive donor to a seronegative recipient) and those that are unexpected despite routine donor screening (ie, human immunodeficiency virus and hepatitis C virus transmitted from a seronegative donor). Expected transmissions occur frequently and screening and prophylaxis strategies are applied to at-risk individuals in nearly all transplant centers globally. Several high profile donor-derived infectious disease transmissions have been recognized; these reports have raised awareness of this rare complication of transplantation. Issues related to the epidemiology of, screening for, and management of proven or probable donor-derived infections are reviewed in this article. |
DOI | 10.1016/j.idc.2010.02.002 |
Alternate Journal | Infect. Dis. Clin. North Am. |
Notify Library Reference ID | 1042 |