| Title | Solid cancers after bone marrow transplantation |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Curtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socie G, Travis LB, Horowitz MM, Witherspoon RP, Hoover RN, Sobocinski KA, F., Fraumeni J. J, D., Roberts J. J |
| Journal | N Engl J Med |
| Volume | 336 |
| Issue | 13 |
| Pagination | 897 - 904 |
| Date Published | 46447 |
| Accession Number | 9070469 |
| Keywords | Adolescent, Adult, Age Factors, Analysis of Variance, Bone Marrow Transplantation / *adverse effects, Child, Female, Follow-Up Studies, Graft vs Host Disease / complications, Hematologic Diseases / therapy, Humans, Incidence, Leukemia / therapy, Male, Neoplasms, Radiation-Induced / etiology, Neoplasms, Second Primary / epidemiology / *etiology, Radiation Dosage, Regression Analysis, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Risk Factors, Time Factors, Whole-Body Irradiation / adverse effects |
| Abstract | BACKGROUND: The late effects of bone marrow transplantation, including cancer, need to be determined in a large population at risk. METHODS: We studied 19,229 patients who received allogeneic transplants (97.2 percent) or syngeneic transplants (2.8 percent) between 1964 and 1992 at 235 centers to evaluate the risk of the development of a new solid cancer. Risk factors relating to the patient, the transplant, and the course after transplantation were evaluated. RESULTS: The transplant recipients were at significantly higher risk of new solid cancers than the general population (observed cases, 80; ratio of observed to expected cases, 2.7; P |
| Notify Library Reference ID | 391 |
