| Title | Prospective evaluation of the threat related to the use of seminal fractions from hepatitis C virus-infected men in assisted reproductive techniques. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Bourlet T, Lornage J, Maertens A, Garret AS, Saoudin H, Tardy JC, Jimenez C, Guerin JF, Pozzetto B, Levy R |
| Journal | Hum Reprod |
| Volume | 24 |
| Issue | 3 |
| Pagination | 530 - 5 |
| Date Published | Mar |
| ISSN | 1460-2350 |
| Accession Number | 19073618 |
| Keywords | Adult, Female, Hepacivirus, Hepatitis C, Humans, Insemination, Artificial, Male, Middle Aged, Prospective Studies, Reproductive Techniques, Assisted, RNA, Viral, Semen, Spermatozoa, Tissue Donors |
| Abstract | The risk of hepatitis C virus (HCV) transmission during assisted reproductive techniques (ARTs) is still disputed and no report concerning its prospective evaluation is available.|The aim of this 4-year follow-up multicentre study that enrolled 86 HCV-serodiscordant couples was to determine whether a sperm-processing method was able to reduce levels of HCV in semen and the risk of HCV transmission to the newborn. All the men were chronically infected by HCV and 10 of them by human immunodeficiency virus. A total of 181 seminal plasmas and 153 sperm fractions were tested for the presence of HCV RNA.|HCV RNA tested positive in 20.4% of the seminal samples. All of the 153 final sperm fractions tested negative for HCV. The detection of HCV RNA in semen was significantly correlated with a high viral load in blood (P |
| DOI | 10.1093/humrep/den414 |
| Notify Library Reference ID | 210 |
