Registry Series: Organ donors with central nervous system tumors. Korean series (2020)

Registry series of 2804 donors (2005-2014, last follow up of recipients in 2017) including 28 donors with primary CNS Malignancy (91 recipients). Note: Non-CNS-malignancy is an absolute contraindication for donation in Korea during study period. 17 donors had tumor diagnosis established by pathology (WHO-grade 1: n=8 (1 case with medulloblastoma), WHO-grade 2: n=3, WHO-grade 3: n=3, WHO-grade 4: n=3) with a different spectrum of interventions (multiple counts: surgery (12), chemotherapy and radiation (4), shunting(1)). From the 6 WHO-grade 3 & 4 "donors" 14 recipients were followed up without signs of malignancy due to brain tumor. From the 11 WHO-grade 1 & 2 "donors" 37 recipients were followed up without signs of malignancy due to brain tumor but one case of recurrent HCC metastasis after 1.1 yrs. post TX, one case thyroid CA after 7.25 years post-transplant and one case of Kaposi-Sarcoma after 2 yrs. post transplant (not specified whether HHV8 Infection of donor or recipient existed). For 4 recipients followup was impossible due to early drop out for other reasons. 11 donors had tumor diagnosis been based on imaging only. In total 34 recipients were without signs of malignancy due to brain tumor, but one case developed renal cell carcinoma after 3.25 yrs. post TX (location not specified), one with cervix carcinoma in situ after 3.5 years post-transplant, one case B-Cell lymphoma 5 yrs. post-TX and one case Colon carcinoma 4.1 yrs. post-TX.