Status:
Ready to upload
Record number:
2095
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Unknown
Time to detection:
Clinical detection three weeks post HCT
Alerting signals, symptoms, evidence of occurrence:
Itching and burning sensation of lips and mouth as well as oral swelling upon kiwi consumption.
Demonstration of imputability or root cause:
Allergic sensitization to kiwi in recipient and donor was proven by ImmunoCAP. Origin of peripheral blood mononuclear cells (PBMCs) was analyzed by chromosomal fluorescence in situ hybridization (FISH). Allergic reaction and activation of hematopoietic cells by customized kiwi extract was confirmed by basophil activation test from whole blood as well as T cell proliferation assays from purified PBMCs of both recipient and donor. FISH analysis proved that hematopoietic cells of the male recipient completely originated from the female donor.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
food allergy
kiwi allergy
Reference attachment:
Suggest references:
Newly Acquired Kiwi Fruit Allergy After Bone Marrow Transplantation From a Kiwi-Allergic Donor. Garzorz et al, J Eur Acad Dermatol Venereol. 2016 Jul;30(7):1136-9