Status:
Ready to upload
Record number:
1904
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Atrial myxomas are not listed in the Council of Europe Guidelines, as they are benign tumors estimated to occur at a rate of 0.5-1 case per million individuals (topic reviewed at http://www.clinicsinsurgery.com/pdfs_folder/cis-v2-id1498.pdf).
Time to detection:
13 years
Alerting signals, symptoms, evidence of occurrence:
Asymptomatic, diagnosed by echocardiography screen
Demonstration of imputability or root cause:
Benign tumor arose in allograft heart (Tumor tissue of same HLA-Typing as donor was type, no HLA-match to recipient)
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Suggest new keywords:
malignancy
myxoma
Case report
Deceased donor
Heart transplant
Reference attachment:
Suggest references:
Bamberg CE, von Ziegler F, Weis F, Beiras-Fernandez A, Schmoeckel M, Meiser B, et al. Donor transmitted left atrial myxoma 13 years after heart transplantation. Annals of transplantation : quarterly of the Polish Transplantation Society. 2011;16(4):118-21.
Note:
Please add "myxoma" as a new category under Malignancy->Soft Tissue/Sarcoma
Carl-Ludwig: did upload the original article, now correct paper.; added HLA typing as method to identify donor origin as this may be helpful as mehtod too.; agree to Michael
Expert comments for publication:
These are benign lesions that occur most commonly in the left atrium. They do have the possibilities of embolization or mitral valve obstruction. Recurrence rate is estimated at 3% following excision.
Since this lesion arose 13 years after transplant, it can be considered to have arisen from donor tissue (donor-derived) but most likely was not transmitted at the time of transplant.