Status:
Ready to upload
Record number:
1867
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
A variety of donor CNS tumor types are represented in this registry series, none of which transmitted tumor to the recipients. Please see individual tumor types in other reports for specific guidance for tumor types (e.g., astrocytoma, pituitary adenoma, etc).
Time to detection:
N/A: No tumors were transmitted in this series of donors with CNS tumors.
Alerting signals, symptoms, evidence of occurrence:
N/A
Demonstration of imputability or root cause:
N/A
Imputability grade:
Not Assessable
Groups audience:
Keywords:
Suggest new keywords:
Registry series
Deceased donor
Lung transplant
Heart transplant
Composite tissue transplant
Astrocytomas and glioblastomas not further specified (WHO grade 1-4)
Ependymoma (WHO grade 2-3)
CNS tumor, other or type not specified
Reference attachment:
Suggest references:
Hynes CF, Ramakrishnan K, Alfares FA, Endicott KM, Hammond-Jack K, Zurakowski D, et al. Risk of tumor transmission after thoracic allograft transplantation from adult donors with central nervous system neoplasm-A UNOS database study. Clin Transplant. 2017;31(4)
Expert comments for publication:
This report summarizes UNOS data of thoracic transplants performed from donors with primary CNS tumors for the period March 1994 through December 2014. Recipients under 18 years of age and recipients in whom data were incomplete were excluded. Of the remaining 58,314 recipients, 337 received organs from donors with primary CNS tumors. No tumor transmission was identified at median followup of 72 months (interquartile range 30-130 months). Tumor histology was known for 89 donors and included oligodendroglioma (17), pituitary adenoma/lesion (17), glioma (8), noncancerous ependymoma (8), astrocytoma (7), glioblastoma (5), low grade ganglioma (3), craniopharyngioma (3), pineal germinoma (2), pinealoma (2), oligoastrocytoma (2), "cytoma" (2), angioblastoma (2), and 1 each of: sellar region tumor, retinoblastoma, likely low grade glioma, keneoblastoma, Hodgkin disease, high-grade glioma, gliomatosis cerebri, germinoma, ganglioglioma, neurocytoma, and acoustic neuroma. The authors conclude that nonmetastatic and benign CNS tumors should not contraindicate use of thoracic organs for transplantation, and that "limited data preclude similar recommendations regarding malignant and aggressive CNS tumors in potential thoracic organ donors".