Status:
Ready to upload
Record number:
1860
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
N/A: 2017 publication of 83 livers transplanted from donors with history of a variety of tumors (see comments, below) without transmission of disease.
Time to detection:
N/A
Alerting signals, symptoms, evidence of occurrence:
N/A: No transmissions
Demonstration of imputability or root cause:
N/A
Groups audience:
Keywords:
References:
Suggest new keywords:
Single center series
Deceased donor
Liver transplant
CNS tumor, other or type not specified
Renal cancer, type not specified
Urinary tract neoplasm, other or type not specified
Skin cancer, other or type not specified
Breast cancer, other or type not specified
Large bowel cancer, other or type not specified
Thyroid cancer, other or type not specified
Lung cancer, type not specified
Leukemia, type not specified
Lymphoma, type not specified
Head and neck cancer, other or type not specified
Malignancy
Prostate adenocarcinoma/carcinoma
Colorectal cancer, type not specified
Reference attachment:
Suggest references:
Benko T, Hoyer DP, Saner FH, Treckmann JW, Paul A, Radunz S. Liver Transplantation From Donors With a History of Malignancy: A Single-Center Experience. Transplant Direct. 2017;3(11):e224.
Note:
Second review done: July 22, 2018 (Kerstin)
Request to the Notify Team: please add "Colorectal cancer" as a key word in our general list (if possible) and add to the list above --> ok (EP)
Expert comments for publication:
A series of 83 liver transplants from donors with a history of cancer (not active cancer). Donor tumors are defined by site of origin, specific histologic types or stages are not given. Donors had a history of CNS tumors (n=27), genitourinary tumors (n=24), skin cancer (n=8), breast cancer (n=10), colorectal cancer (n=5), thyroid cancer (n=2), lung cancer (n=3), hematologic malignancy (n=3), or laryngeal cancer (n=1). Overall donor tumor free intervals are provided. Recipient follow-up ranged from 0-155 months, median 19.9 months. Of the 83 recipients, 13 died within 30 days due to unrelated causes.
Reviewer´s remark: The missing histological type in most of the decribed tumors in this study makes it difficult to assess the real tumor transmission risk in the analysed study population: there is a big difference between e.g. melanoma and basal cell carcinoma which are both grouped into skin cancers.