TPE (therapeutic plasma exchange) complications

Status: 
Ready to upload
Record number: 
1757
Adverse Occurrence type: 
Other
MPHO Type: 
Plasma
Estimated frequency: 
30% of patients undergoing TPE for TTP had a major complication during 2011-14. No fatalities.
Time to detection: 
Not stated
Alerting signals, symptoms, evidence of occurrence: 
Clinical changes
Demonstration of imputability or root cause: 
This report presents updated information from that in record number 1756
Imputability grade: 
2 Probable
Groups audience: 
Clinical complications
Keywords: 
TPE (therapeutic plasma exchange)
TTP (thrombotic thrombocytopenic purpura)
TTP-HUS (thrombotic thrombocytopenic purpura-hemolytic uremic syndrome)
plasma
References: 
Plasma exchange complications in patients treated for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: 2011 to 2014
Decreasing frequency of plasma exchange complications in patients treated for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome, 1996 to 2011.
Suggest new keywords: 
threapeutic plasma exchange
Reference attachment: 
PDF icon McClain2014.pdf
Suggest references: 
McClain RS, et al. Plasma exchange complications in patients treated for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: 2011 to 2014. Transfusion 2014: 54: 3257-59
Note: 
similar information in full length publication (record number 1756) 2/3's of major complications were catheter related, 1/3 were plasma related. TPE stopped in 1/3 of those with complications.
Expert comments for publication: 
This letter-to-the-editor presents updated, but not new information than that reported in a previous full publication (record number 1756)