Chlamydia pneumoniae

Status:

Ready to upload

Record number:

997

Adverse Occurrence type:

Chlamydia

MPHO Type:

Lung

Time to detection:

1 - 2,475 days

Alerting signals, symptoms, evidence of occurrence:

Impact of C. pneumoniae on bronchiolitis obliterans syndrome (BOS) development using donor-recipient serology obtained before transplantation in a cohort of 76 lung transplant recipients (LTR).

Demonstration of imputability or root cause:

The risk of developing BOS was 75.0% in the case of a primary seromismatch for C. pneumoniae (D+/R-), whereas a reverse mismatch had a risk of 4.6% (likelihood ratio 9.8, P=0.02). Possibility of wrongly categorizing C. pneumoniae serostatus in LTR as seroconversion within the 6-month sampling period before transplantation.

Groups audience:

Infections -- Bacteria

Keywords:

Chlamydia pneumoniae

lung transplantation

BOS (bronchiolitis obliterans syndrome)

IgG (immunoglobulin G)

mismatch

seroconversion

References:

Chlamydia pneumoniae Serology in Donors and Recipients and the Risk of Bronchiolitis Obliterans Syndrome after Lung Transplantation.

Suggest references:

Kotsimbos TC, Snell GI, Levvey B, Spelman DW et al. Chlamydia pneumoniae serology in donors and recipients and the risk of bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2005 Feb 15;79(3):269-75.