Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Pure red cell aplasia.
Demonstration of imputability or root cause:
Parvovirus B19 DNA was detected by polymerase chain reaction (PCR) in the serum, drawn on day 90 after bone marrow transplantation, and in a cryovial of stored original peripheral blood progenitor cell (PBPC). The authors speculate that parvovirus contaminated progenitor cells, infused after high-dose chemotherapy, may have contributed to the delay in red blood cell engraftment and subsequent pure red cell aplasia, 3 months after autologous bone marrow transplantation.
Arnold, D.M.; Neame, P.B.; Meyer, R.M.; Soamboonsrup, P.; Luinstra, K.E.; O'Hoski, P.; Garner, J.; Foley, R. Autologous peripheral blood progenitor cells are a potential source of parvovirus B19 infection Transfusion 2005; 45 (3) :394 - 8