Record number:
915
Adverse Occurrence type:
MPHO Type:
Alerting signals, symptoms, evidence of occurrence:
Birth of 5 newborns with Neurofibromatosis type 1 (NF 1) following sperm donation
Demonstration of imputability or root cause:
Thorough genetic analysis of the donor sperm demonstrated an intragenic deletion spanning exon 11-23.1 in the NF1 gene and revealed a germ line mosaicism of approximately 20% (3). In a letter to the involved Danish fertility clinics the involved cryobank informed of an expected risk of 10-20 % for NF1 inheritance among the donor offspring
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AAA