Case report: Choriocarcinoma (2010)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Most recent risk assessment for choriocarcinoma (Council of Europe, 2022): Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.
Time to detection: 
1 month
Alerting signals, symptoms, evidence of occurrence: 
Increased Human Chorionic Gonadotropin (hCG) levels and intestinal tumor suggesting a metastasis. No histology reported..
Demonstration of imputability or root cause: 
Condition known in the donor. She was a 26-year-old pregnant woman who died from a cerebral hemorrhage initially attributed to a vascular malformation. Histological examination demonstrated the presence of a placental choriocarcinoma three weeks after donation. More than one recipient affected from the same donor with elevated HCG levels.
Imputability grade: 
2 Probable
Groups audience: 
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Case Report
Deceased donor
Liver transplant
Germ cell, sex cord and related tumors
Patient death
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