Leukoencephalopathy

Record number: 
709
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
Immediate
Alerting signals, symptoms, evidence of occurrence: 
Posterior reversible leukoencephalopathy (PRL) following the infusion of dimethylsulfoxide (DMSO) cryopreserved autologous stem cells. headache, altered mental status, seizures and visual changes
Demonstration of imputability or root cause: 
Magnetic resonance (MR) imaging revealed white matter changes which resolved over the next 2 months.