Late endothelial failure

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Alerting signals, symptoms, evidence of occurrence: 
Graft failure. No apparent cause, unresponsiveness to corticosteroids, no recent history of a rejection episode
Demonstration of imputability or root cause: 
Grafts with insufficient endothelial cells developed late endothelial failure. The main cause of graft failure after the first 5 postoperative years Accounts for over 90% of failures between 5 and 10 years after PK. Can be elicited by complications during follow up (previous ocular hypertension, rejection episodes, etc.), therefore not easily attributable to tissues properties.