Registry series: Acute myeloid leukemia (AML) after stem cell transplant (2005)

Record number:

681

Adverse Occurrence type:

Leukemia, myeloid, acute myelogenous (includes myeloid sarcoma)

MPHO Type:

Marrow

Estimated frequency:

7/10489

Time to detection:

17 (4-164) months

Alerting signals, symptoms, evidence of occurrence:

Elevated blood counts; anemia; thrombopenia. 17 (4-164) months from SCT

Demonstration of imputability or root cause:

Case 1: cytogenetics and molecular marker. Case 2: Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin.

Imputability grade:

3 Definite/Certain/Proven

Keywords:

cytogenetics

anemia

FISH (fluorescence in situ hybridization)

karyotype

malignancy

AML (acute myeloid leukemia)

allogeneic

thrombocytopenia

References:

Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT)

Acute Myeloid Leukemia of Donor Origin After Allogeneic Bone Marrow Transplantation for Precursor T-Cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

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