Record number:
68
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for leukemia, lymphoma and plasmacytoma (Council of Europe, 2022):
Leukaemia, lymphoma and plasmacytoma diagnosed during donor procurement: These cancers are classified as an unacceptable risk for organ donation. Leukaemia, lymphoma and plasmacytoma in the donor history: Active (acute or chronic) leukaemia, lymphoma and plasmacytoma are an unacceptable risk for organ donation. Treated acute leukaemia and lymphoma after a definite disease-free interval of 10 years may be considered for organ donation with an assumed high risk for transmission.
Time to detection:
24 months
Alerting signals, symptoms, evidence of occurrence:
Unspecific symptoms, ecchymosis, thrombocytopenia and disseminated intravascular coagulation. Leukemic cells in blood smear. Bone marrow aspiration and biopsy confirm diagnosis.
Demonstration of imputability or root cause:
DNA studies confirm donor origin (unique sex chromosome-male to female donation- and donor HLA markers). T-translocation only present in male cells.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
Patient death
Neoplasia
Case Report
Deceased donor
Liver transplant
DNA typing
Immunohistochemistry
Blood and lymphoid
Promeylocytic leukemia
Cytogenetic analysis
Suggest references:
1. Bodo I, Peters M, Radich JP, Hess J, Blinder M, Watson MS, et al. Donor-derived acute promyelocytic leukemia in a liver-transplant recipient. N Engl J Med. 1999 ed. 1999 Sep 9;341(11):807–13.