Adverse Occurrence type:
Time to detection:
10 - 30 days
Alerting signals, symptoms, evidence of occurrence:
Fever, intravascular hemolysis, thrombocytopenia, blood smear, transaminitis, renal failure, neurological symptoms, coma, multi-organ failure; asymptomatic parasitemia
Demonstration of imputability or root cause:
In all cases, donor had been to or resided in a malaria endemic region (sometimes long before donation), was asymptomatic and was tested retrospectively. Recipients from common donors became infected and those who were diagnosed very early and treated pre-emptively did well, in contrast to symptomatic patients. (Ref 113) West African, asymptomatic donor found retrospectively to be seropositive, with Plasmodium falciparum found in blood > 1 year after having left Cameroon. Recipient of heart diagnosed day 18, trophozoites in thin smear, died of malaria. Recipient of one of the kidneys had Plasmodium falciparum detected in blood but died of disseminated CMV infection.
Posttransplant malaria: first case of transmission of Plasmodium falciparum from a white multiorgan donor to four recipients.
Fever, mental impairment, acute anemia, and renal failure in patient undergoing orthotopic liver transplantation: posttransplantation malaria.