Adverse Occurrence type:
Time to detection:
5 - 13 days
Alerting signals, symptoms, evidence of occurrence:
Fever, anemia, thrombocytopenia, blood smear, transaminitis, renal failure, neurological symptoms, coma, multi-organ failure; asymptomatic parasitemia
Demonstration of imputability or root cause:
In all cases, donor had been to or resided in a malaria endemic region (sometimes long before donation), was asymptomatic and was tested retrospectively. Recipients from common donors became infected and those who were diagnosed very early and treated pre-emptively did well, in contrast to symptomatic patients. (Ref 113) West African, asymptomatic donor found retrospectively to be seropositive, with Plasmosium falciparum found in blood > 1 year after having left Cameroon. Recipient of heart diagnosed day 18, trophozoites in thin smear, died of malaria. Recipient of one of the kidneys had Plasmodium falciparum detected in blood but died of disseminated CMV infection. (Ref 335) Donor returned from Togo 10 days before donation, retrospectively tested positive (serology and blood film). Recipients of liver, heart and both kidneys became infected. High parasitemia and significant symptoms in liver and heart recipients. Renal recipients treated pre-emptively, remained asymptomatic.