Creutzfeldt-Jacob disease (CJD)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
79 months
Alerting signals, symptoms, evidence of occurrence: 
A 35 year old man received a Lyodura dura allograft in 1991 during surgical repair of a skull fracture. In 1997, 79 months later, he developed unsteady gait, dysmetria, dyskinesia, and myoclonic jerks and died 4 months after onset of symptoms of CJD proven at autopsy.
Demonstration of imputability or root cause: 
Level 3. Likely, probable transmission. Although no clinical information was known about the donor, the dura recipient died of autopsy-proven CJD and was one of over a hundred others worldwide dying of CJD acquired from contaminated freeze-dried, Lyodura brand, dura mater allograft made by pooled processing involving dura from many inadequately screened donors by B. Braun Melsungen AG, Germany
Imputability grade: 
2 Probable
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