Creutzfeldt-Jacob disease (CJD)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
120 months
Alerting signals, symptoms, evidence of occurrence: 
In 1994, a 51 year old man in France underwent spine surgery for paraplegia due to trauma using Lyodura dura allograft. After 120 months he developed lack of coordination of arms,diplopia, dysarthria, progressing to myoclonic jerks and death 2 months after onset of symptoms. No postmortem histologic exam of the brain.
Demonstration of imputability or root cause: 
Level 2. Possible transmission of CJD via dura transplantation. The dura brand, Lyodura, used in this case had been implicated in causing CJD in over a hundred recipients. No donor data available. Although there was no histologic exam of his brain, the patient died of an illness typical of CJD 
Imputability grade: 
1 Possible
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