Human Immunodeficiency Virus (HIV)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Alerting signals, symptoms, evidence of occurrence: 
Four of eight recipients of artificial insemination (AI) with cryopreserved semen from a symptomless carrier of human T-cell lymphotropic virus type III (HTLV-III) were found to have antibody to the virus. One had generalised, persistent lymphadenopathy while the other three remained symptom free 3 years after insemination. (Note: this was before washing of sperm prior to insemination had become routine).
Demonstration of imputability or root cause: 
Antibody negative recipients seroconverted after artificial insemination from a single donor. Three children born were antibody negative 1 year after birth.
Imputability grade: 
3 Definite/Certain/Proven
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