Herpes simplex virus (HSV)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
5 days
Alerting signals, symptoms, evidence of occurrence: 
Primary graft failure and epithelial defects and deterioration leading to graft failure
Demonstration of imputability or root cause: 
Proven - Viral culture of swabs taken from corneas during the early postoperative period. Failed donor corneas were examined histopathologically by immunohistochemistry (IHC) for HSV-1 antigens, transmission electron microscopy (TEM), and by polymerase chain reaction (PCR) for HSV DNA. Infection confirmed.
Imputability grade: 
3 Definite/Certain/Proven
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