Record number:
555
Adverse Occurrence type:
MPHO Type:
Time to detection:
6 weeks
Alerting signals, symptoms, evidence of occurrence:
Transmission of HCV. Co-transmission with HIV to multiple recipients by multiple organs. Marked allograft disfunction and liver biopsy showed changes consistent with mild lobular hepatitis 6 weeks post-txp. Lab Results: HIV ab positive, low to low normal HIV viral loads, low CD4 cell counts, HCV ab negativ, high HCV viral loads.
Demonstration of imputability or root cause:
Genetic sequences were highly related between between HCV and HIV strains infecting all 4 recipients, confirming transmission from a common donor. HCV in sera of all recipients was genotype 1a. HIV gag and evn sequence from donor and recipients were identical except for a single nucleotide difference found in liver recipient. Donor was negative for HCV and HIV by serology; had engaged in MSM behavior.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
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