Record number:
535
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
"the cumulative probability of CMV seroconversion was 0.31 by 36 days after first exposure to CMV-seropositive cadaver skin allografts". Five (22.7 percent) of 22 patients seroconverted during hospitalization at a mean of 34.2 days (25-46 days) after the burn and 26.7 days (21-42 days) after receipt of skin.
Time to detection:
21-42 days
Alerting signals, symptoms, evidence of occurrence:
A 1996 report of a study of 22 CMV negative burn patients who received skin allografts without regard to the donor's CMV serum status (90.9% of skin allografts were seropositive) showed that ski allografts can transmit CMV. They received CMV-seronegative blood products. Of 493 patients admitted from 1989 to 1993, 22 were CMV seronegative Five (22.7 percent) of 22 patients seroconverted during hospitalization at a mean of 34.2 days (25-46 days) after the burn and 26.7 days (21-42 days) after receipt of skin. One of five had CMV pneumonia develop, two had CMV viruria develop, and three had persistent fever (>38.9 C), abnormal liver enzymes, and diarrhea not ascribable to bacterial or other viral agents. Another 4 patients became seropositive T 50, 163, 184, and 202 days after discharge but these were not considered as possible skin transmission cases.
Demonstration of imputability or root cause:
Level 2. Likely, probable. CMV seroconversion after skin transplant, several with clinical disease consistent with CMV infection. No other viral or bacterial cause found
Imputability grade:
1 Possible
Keywords:
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