Record number:
481
Adverse Occurrence type:
MPHO Type:
Time to detection:
3 - 13 days
Alerting signals, symptoms, evidence of occurrence:
Asymptomatic (~80%) in the majority of immunocompetent individuals;
Fever, thrombocytopenia; diarrhea; acute flaccid paralysis; meningoencephalitis; Neuroinvasive illess (WNND) in 40-60% of immunocompromised hosts.
Demonstration of imputability or root cause:
Demonstration of recent WNV infection in donors through IgM and PCR testing. One donor infection identified through mandatory Nucleic Acid testing (NAT) in a region of high WNV activity. Nearly all recipients became infected shortly after transplant as demonstrated by Nucleic acid test (RTPCR), IgM and IgG in serum or CSF; some cases were tested by immunohistochemical staining of tissue and by viral isolation.
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References:
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AAA