West Nile Virus

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
11 - 17 days
Alerting signals, symptoms, evidence of occurrence: 
Asymptomatic (~80%) in the majority of immunocompetent individuals; Fever, malaise, myalgia, arthralgia, maculo-papular rash, diarrhea, meningitis, encephalitis,   Neuroinvasive illess (WNND) in 40-60% of immunocompromised hosts.
Demonstration of imputability or root cause: 
Donors had demonstrable markers of recent WNV infection at the time of organ recovery (retrospective testing). 85% of organ recipients (11/13) became infected within 2 weeks from transplant as demonstrated by Nucleic acid test (RTPCR), IgM and IgG in serum or CSF. The vast majority had clinical manifestations, mainly neurological.
Imputability grade: 
3 Definite/Certain/Proven
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