West Nile Virus

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
5 - 10 days
Alerting signals, symptoms, evidence of occurrence: 
Asymptomatic (~80%) in the majority of immunocompetent individuals; West Nile fever, malaise, myalgia, lymphadenopathy, meningitis, encephalitis. Neuroinvasive disease (WNND) in 40-60% of immunocompromised hosts.
Demonstration of imputability or root cause: 
WNV RNA by Reverse Transcription Polymerase Chain Reaction (RTPCR) in serum, CSF and tissues, Serology CSF/serum IgM capture, IgG; Neutralising antibodies (reference method), virus isolation. Immunohistochemical staining of tissues. Donors had laboratory proven evidence of recently acquired WNV infection, and all 5 recipients became infected within weeks from transplantation. Most developed neurological symptoms.
Imputability grade: 
3 Definite/Certain/Proven
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