Trypanosoma cruzi

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Review of literature in 2005 (ref 131)  shows T. cruzi transmission in 12 (35%) of 34 of initially seronegative patients who received a kidney from a seropositive donor . Argentinian seried (ref 1316) shows 18.7% rate.
Time to detection: 
21 days - 3 months
Alerting signals, symptoms, evidence of occurrence: 
Asymptomatic parasitaemia; parasitaemia; cutaneous panniculitis; myalgia; fever; apathy;
Demonstration of imputability or root cause: 
Brazilian cases (ref 507): Two seronegative kidney recipients from same donor developed Chagas disease post transplant. Donor not tested. Argentinian series (ref 1316): When there was serological mismatch, ie D+/R- for T.cruzi, 3 out 16 recipients (18.7%) developed infection. This was determined by weekly surveillance testing for parasitaemia and serology. Infected recipients were preemptively treated with nifurtimox or benznidazole.   
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