Adverse Occurrence type:
Review of literature in 2005 (ref 131) shows T. cruzi transmission in 12 (35%) of 34 of initially seronegative patients who received a kidney from a seropositive donor . Argentinian seried (ref 1316) shows 18.7% rate.
Time to detection:
21 days - 3 months
Alerting signals, symptoms, evidence of occurrence:
Asymptomatic parasitaemia; parasitaemia; cutaneous panniculitis; myalgia; fever; apathy;
Demonstration of imputability or root cause:
Brazilian cases (ref 507): Two seronegative kidney recipients from same donor developed Chagas disease post transplant. Donor not tested. Argentinian series (ref 1316): When there was serological mismatch, ie D+/R- for T.cruzi, 3 out 16 recipients (18.7%) developed infection. This was determined by weekly surveillance testing for parasitaemia and serology. Infected recipients were preemptively treated with nifurtimox or benznidazole.
Doardes cadaveres com sorologia positiva para doenca de Chagas o devem ser utilizados como fonte de orgaos para transplante renal?
Transmission of Chagas' disease through transplanted kidney: occurrence of the acute form of the disease in two recipients from the same donor