Toxoplasma gondii (Toxoplasmosis)

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Two large series of 4,312 and 662 BMT patients, showed incidences of 0.28% and 0.45% but most published cases are of reactivation, as recipient seropositive pre-transplantation 
Time to detection: 
7 days - 6 weeks
Alerting signals, symptoms, evidence of occurrence: 
fever, cardiomyopathy, encephalitis, respiratory failure
Demonstration of imputability or root cause: 
Possible in some cases, as recipient seronegative pre-transplant but donor serostatus not always available;  majority of cases reported are not due to graft-related infection (cases of non primary toxoplasmosis)