Adverse Occurrence type:
6 of 7709 cases (0.08%) in a multicentre, matched case-control, study in Spain
Time to detection:
15 - 180 days
Alerting signals, symptoms, evidence of occurrence:
Analysis reported 85% presented with fever, followed by pulmonary symptoms; 69% with hematological abnormalities. Transaminitis, splenomegaly, lymphadenopathy. High mortality during the early post -transpant period; Late presentation seen after interruption of Trimethoprim-Sulphametoxazole (TMP-SMX) prophylaxis is associated with better prognosis.
Demonstration of imputability or root cause:
Imputability based on donor seropositive/recipient seronegative mismatch followed by IgG seroconversion and detectable IgM in the early post transplant period. Histopathologic examination, autopsy, Polymerase chain reaction (PCR) of tissue material. In cases where seroconversion happened later in the post-transplant period, it is likely that the infection was not acquired through the graft.