Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
A 14-year-old girl from the UK underwent volunteer unrelated donor bone marrow transplant (VUD BMT) for accelerated phase chronic myeloid leukaemia. On day +40: fever, rigors, non-focal exam.
Demonstration of imputability or root cause:
Recipient with no previous history of malaria and no travel history outside the UK, had positive blood smear. Donor had a documented Plasmodium vivax infection during a vacation in Papua New Guinea. Following appropriate treatment, he had been asymptomatic for 11 months before marrow harvesting. Potential problem of recrudescence of latent, dormant forms of Plasmodium vivax infection following transplantation into an immuno-compromised recipient.