Denovo development of corneal guttae and Fuchs' dystrophy in corneal grafts

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
4-10 years
Alerting signals, symptoms, evidence of occurrence: 
Corneal guttae were first noted 10 years and 4 years following transplantation in the first and second patient, respectively. In both cases, the corneal guttae gradually increased in number, involving the central and temporal portions of the corneal graft There were no corneal guttae present in the host corneal rim or contralateral cornea of either patient.
Demonstration of imputability or root cause: 
These cases provide evidence to suggest that some corneas may be genetically predetermined to develop corneal guttae and Fuchs' dystrophy many years before any changes can be clinically detected.
Imputability grade: 
3 Definite/Certain/Proven
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