Record number:
336
Adverse Occurrence type:
MPHO Type:
Time to detection:
6 months
Alerting signals, symptoms, evidence of occurrence:
Fever and non specific abdominal complaints 6 months after tx. Large central liver mass. No extra-hepatic involvement. Poorly differentiated squamous cell carcinoma, unresectable at exploration. The patient was treated with chemoembolization, systemic chemotherapy and cessation of immunosuppression. Repeat biopsy 2 months later revealed tumor to be completely necrotic. Second liver transplant performed due to acute and chronic rejection of first graft and disease free 2 years after.
Demonstration of imputability or root cause:
Two kidneys, heart and liver transplanted from the same donor. Only liver affected. Heart tx died 10 months after tx with no tumor, because of pneumonia. Both kidney tx well 3 years after tx. Histocompatibility testing using PCR amplification techniques identified both donor and recipient alleles.
Imputability grade:
3 Definite/Certain/Proven
Keywords:
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