Adverse Occurrence type:
Most recent risk assessment for sarcoma (Council of Europe, 2022): Due to the very aggressive behavior of sarcoma, they are considered an unacceptable risk for organ donation at any stage of disease. Sarcoma in donor history: Because of the very aggressive behavior of sarcoma, they are mostly considered an unacceptable risk for organ donation. After curative treatment and a recurrence-free survival of > 5 years, sarcomas are still assumed to be associated with a high risk for transmission.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Kidney: 1 year after transplantation graft was removed for a malignant graft tumor, proven to be a spindle cell sarcoma.
Demonstration of imputability or root cause:
- DCD with liver and kidneys transplanted. Liver and one of the kidney recipients affected. Second kidney with PNF removed shortly after Tx. No evidence of tumor 15 months later. - Histology of tumors found in liver and kidney recipients histologically comparable. - Kariotype gender mismatch in liver recipient (donor female-recipient male).
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