Record number:
326
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for sarcoma (Council of Europe, 2022):
Due to the very aggressive behavior of sarcoma, they are considered an unacceptable risk for organ donation at any stage of disease. Sarcoma in donor history: Because of the very aggressive behavior of sarcoma, they are mostly considered an unacceptable risk for organ donation. After curative treatment and a recurrence-free survival of > 5 years, sarcomas are still assumed to be associated with a high risk for transmission.
Time to detection:
42 M
Alerting signals, symptoms, evidence of occurrence:
3.5 years after transplantation, routine control ultrasound and later CT shows a 6 cm tumor in the right posterior sector of the graft. Right hepatectomy of the tumor performed. Histology compatible with high grade sarcoma. Patient well 1.5 years after resection after described surgery and reduction of immunosuppression.
Demonstration of imputability or root cause:
Donor condition unknown. Two kidneys, liver, skin (two recipients), bone (11 recipients) and cornea recipients. Only liver recipient affected. Liver recipient transplanted because of a hepatitis B cirrhosis with HCC found in explanted liver. Microsatellite analysis was performed on the DNA of the donor (liver allograft), recipient (perpheral blood) and tumor tissue, the study detemining the donor origin of the tumor.
Imputability grade:
2 Probable
Keywords:
References:
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