Record number:
306
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for neuroendocrine tumors (including high grade neuroendocrine carcinomas, low(er) grade neuroendocrine tumors, carcinoid tumors, pheochromocytomas and paragangliomas) (Council of Europe, 2022):
Due to their potential for undetected metastasis, high-grade neuro-endocrine carcinomas are an unacceptable risk for organ donation. Insufficient information exists to guide practice for neuro-endocrine tumours, carcinoid tumours, phaeochromocytomas and paragangliomas. In the case of critically ill recipients, these tumours might be acceptable after a careful individual risk–benefit analysis. Neuro-endocrine tumours in the donor history: No data are available from the literature. Due to this and their potential for undetected metastasis, treated high-grade neuro-endocrine neoplasms in the donor history are classified as high risk for organ donation. In the case of a previous history (> 5 years) of neuro-¬endocrine tumours (carcinoid tumours, phaeochromocytomas and paragangliomas) without any kind of disease recurrence or progression, donors should be considered high risk in the absence of sufficient information to guide practice.
Time to detection:
12 months
Alerting signals, symptoms, evidence of occurrence:
Not specified. Poorly differentiated malignancy probably of neuroendocrine origin.
Demonstration of imputability or root cause:
Liver and two kidneys transplanted. Two recipients from the same donor reported to be affected.
Imputability grade:
2 Probable
Groups audience:
Suggest new keywords:
registry series
liver transplant
kidney transplant
Reference attachment:
Suggest references:
aaa
Expert comments for publication:
Limited information available as this is a registry report. Highly probable that this is a transmitted tumor, since it was poorly differentiated and two recipients from the same donor developed similar tumor.