Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
3 weeks
Alerting signals, symptoms, evidence of occurrence: 
74 yr old Female. PK for bullous keratopathy followed by retrocorneal membrane, glaucoma 6 months later (exam:retained Decemet's membr, stromal edema, epith.haze, punctate epithelial erosions).. Regrafted (PK#2): Explanted PK#1 cornea: no Acanthamoeba. 3 weeks later developed inferior stromal keratitis, epithelial defect, hypopyon. Regrafted again (PK#3):Explanted PK#2 cornea: Acanthamoeba cysts and trophozoites. PK using other cornea from donor did not result in infection. PK#3 progressed to enucleation. Histology of cornea of PK#3 showed Acanthamoeba cysts
Demonstration of imputability or root cause: 
Level 2 Possible transmission by PK. No other environmental or patient risk factors. No infection from mate cornea. Uncertain origin, thus possibly allograft related.
Imputability grade: 
1 Possible
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