Record number:
283
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for melanoma (Council of Europe, 2022): Due to the very aggressive behaviour of this tumour, it is considered an unacceptable risk for organ donation.
Malignant melanoma in the donor history: Due to the lack of exhaustive data, transplanting organs from donors with treated malignant melanoma must still be considered to be associated with a high transmission risk. If precise donor data about staging, therapy, follow-up and recurrence-free survival are available, and evaluation by the dermato-oncologist concludes there is a low probability of recurrence and metastasis, organ donation might be considered for selected recipients.
Time to detection:
3 - 8 months
Alerting signals, symptoms, evidence of occurrence:
Alerting signals not detailed. Patient one, who received agressive chemotherapy, died at 8 months after transplantation with metastasis. Patient two, who did not receive chemotherapy, died of metastatic disease 3 months after transplantation.
Demonstration of imputability or root cause:
Assessment of disease transmission studied by biopsy confirmatory with comparison of the recipient cancer to the primary donor tumour or in some cases genetic allelic analysis (not specified in this particular case). It is literally said: 'diffuse transmission of diffuse metastatic disease eventually occurred.'
Imputability grade:
2 Probable
Groups audience:
Keywords:
Suggest new keywords:
Registry series
Heart transplant
Decease donor
Suggest references:
AAA