Record number:
273
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for leukemia, lymphoma and plasmacytoma (Council of Europe, 2022):
Leukaemia, lymphoma and plasmacytoma diagnosed during donor procurement: These cancers are classified as an unacceptable risk for organ donation. Leukaemia, lymphoma and plasmacytoma in the donor history: Active (acute or chronic) leukaemia, lymphoma and plasmacytoma are an unacceptable risk for organ donation. Treated acute leukaemia and lymphoma after a definite disease-free interval of 10 years may be considered for organ donation with an assumed high risk for transmission.
Time to detection:
10 months
Alerting signals, symptoms, evidence of occurrence:
Graft removed 10 months after transplantation due to chronic rejection. Histology shows a non-Hodgkin's lymphoma of polymorphous centroblastic in the graft.
Demonstration of imputability or root cause:
The HLA patterns of the renal allograft and the recipient differed at two loci, the donor origin of the malignancy could be demonstrated by immunohistochemistry.
Imputability grade:
1 Possible
Suggest references:
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