Registry series: Germ Cell Cancer (2008)

The Council of Europe does not deal with germ cell cancer as a category but has more generalized guidelines for testicular and ovarian cancers, as well as CNS germ cell tumors. Testicular cancer: Most recent risk assessment for testicular cancer (Council of Europe, 2022): No literature exists regarding newly diagnosed testicular cancer and organ donation. Therefore, the highest caution is recommended. Testicular tumour in donor history: Given the good treatment response of testicular tumours in general and stage 1 tumours in particular, a stage 1 tumour with at least 5 years recurrence-free follow up is likely to be associated with minimal risk. Ovarian cancer: Most recent risk assessment for ovarian cancer (Council of Europe, 2022): Ovarian cancer is considered an unacceptable risk for organ donation. Ovarian cancer in the donor history: Treated ovarian cancer is considered high-risk for organ donation. Depending on initial stage, grade, therapy and time of recurrence-free survival (> 5 years), the risk category might decrease individually. CNS germ cell tumors: Most recent risk assessment for CNS germ cell tumors (Council of Europe, 2022): Organs from potential donors with mature teratomas represent a minimal risk of tumour transmission. Organs from donors with other germ cell tumours should be considered intermediate to high risk for tumour transmission, depending on the different international recommendations, which will be adjusted with increasing evidence. The transmission risk is further increased in cases with previous interventions such as tumour resection, ventriculo-¬peritoneal/-atrial drainage and/or cranial chemo-/radiotherapy.