Record number:
250
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for choriocarcinoma (Council of Europe, 2022):
Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.
Time to detection:
6 months
Alerting signals, symptoms, evidence of occurrence:
Not specified. Thoracic and distant metastases with death 6 months after transplantation.
Demonstration of imputability or root cause:
Assessment of disease transmission studied by biopsy confirmatory with comparison of the recipient cancer to the primary donor tumour or in some cases genetic allelic analysis. In this particular case, the same histological type of tumour was known to be present in the donor (identified as having an occult choriocarcinoma after donation and implantation), with no further specification provided.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
Registry series
Deceased donor
Heart transplant
Suggest references:
AAA