Record number:
245
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
- Most recent risk assessment for leukemia, lymphoma and plasmacytoma (Council of Europe, 2025):
Leukaemia, lymphoma and plasmacytoma diagnosed during donor procurement: These cancers are classified as an unacceptable risk for organ donation.
Leukaemia, lymphoma and plasmacytoma in the donor history: Active (acute or chronic) leukaemia, lymphoma and plasmacytoma are an unacceptable risk for organ donation. Treated acute leukaemia and lymphoma after a definite disease-free interval of 10 years may be considered for organ donation with an assumed high risk for transmission.
Alerting signals, symptoms, evidence of occurrence:
The pre-transplant leukemia was of T cell origin whereas the post-transplant relapse leukemia was of B cell origin
Demonstration of imputability or root cause:
The recurrence was shown to be in donor cells by analysis of chromosomes and restriction fragment length polymorphisms.
Keywords:
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