Case report: Acute Monocytic Leukemia (AML)

Record number: 
240
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
9 months
Alerting signals, symptoms, evidence of occurrence: 
thrombocytopenia
Demonstration of imputability or root cause: 
Cytogenetics (XX) and PCR
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
Leukemia, monocytic, acute
Living donor
Case report
Allogeneic bone marrow transplant
Bone marrow allograft transplant
Suggest references: 
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Expert comments for publication: 
An important observation is the fact that the donor did not have leukemia or show evidence of the translocation and remains well, and the recipient had an earlier posttransplant karyotype that was normal. This leads to the conclusion that, although the leukemia is arising from donor cells, it is most likely a post-transplant event. In the terminology of solid organ transplantation, it can be considered a "donor derived" but not "donor transmitted" cancer.