Single center series: Malignancies transmitted by kidney transplant: probable cholangiocarcinoma (2016)

This single center series reports three different malignancies which are donor transmitted or donor derived: Case 1: Meningioma: (Council of Europe, 2018): Extra-neural metastases by histologically benign meningiomas are very rare. Organs from potential donors with these types of tumours have a minimal risk of transmission. Anaplastic or malignant meningiomas (WHO grade III) are more aggressive meningeal tumours that occasionally can be associated with extra-neural metastases. Organs from potential donors with these tumours are considered low to intermediate risk if no risk factors are present. The transmission risk of anaplastic or malignant meningiomas is increased (high risk) in cases with previous interventions such as tumour resection, ­ventriculo-peritoneal/-atrial drainage and/or cranial chemo-/radiotherapy. Case 2: Urothelial Carcinoma Most recent risk assessment for urothelial carcinoma (Council of Europe, 2018): No literature exists regarding newly diagnosed urothelial cancer and organ donation. Therefore, the highest caution is recommended and the advice of a urologist may be sought in assessing the individual donor tumour transmission risk. National recommendations should be followed since they vary in accepting these tumours. In the case of patients with a history of urothelial carcinoma, it must be remembered that these tumors tend to be multicentric and can recur. Kidney transplantation is considered to be associated with an increased risk but the extent of this has not been classified. Similarly, potential donors with a past history of urothelial carcinoma and a disease free interval of at least 5 years should be assessed based on estimate of the probability of cure. No specific recommendations are available from the literature. Case 3: adenocarcinoma of unknown origin (suspected to be cholangiocarcinoma but unproven): no estimate possible.