Status:
Ready to upload
Record number:
2236
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Delayed adverse reactions are observed in 19.2% of platelet pheresis donors, compared to 5.46% of immediate adverse reactions.
Localized reactions (bruises, sore arm) are more common at 16.01% compared to systemic reactions (vasovagal reactions, fatigue) at 3.2%.
Donor adverse reactions are reported by 6.96% of first-time donors compared to only 1.6% of repeat donors.
Time to detection:
Between 24 hours and two weeks after collection.
Alerting signals, symptoms, evidence of occurrence:
Observational study based on donor reporting.
Demonstration of imputability or root cause:
Donor self-reporting after being contacted by blood center staff, not clear if the systemic reactions are related to collection, although the localized ones are likely to be related.
Imputability grade:
2 Probable
Groups audience:
Keywords:
References:
Suggest new keywords:
Localized adverse reactions, systemic adverse reactions, hematomas, vasovagal reactions, platelet pheresis
Reference attachment:
Suggest references:
Crocco A, D'Elia D. Adverse reactions during voluntary donation of blood and/or blood components. A statistical-epidemiological study. Blood Transfus. 2007 Jul;5(3):143-52. doi: 10.2450/2007.0005-07. PMID: 19204767; PMCID: PMC2535889.
Working Group on Donor Vigilance of the International Society of Blood Transfusion Working Party on Haemovigilance, The International Haemovigilance Network, The AABB Donor Haemovigilance Working Group. Standard for surveillance of complications related to blood donation. Standard for Surveillance of Complications Related to Blood Donation; 2014.
Land KJ, Townsend M, Goldman M, Whitaker BI, Perez GE, Wiersum-Osselton JC. International validation of harmonized definitions for complications of blood donations. Transfusion. 2018 Nov;58(11):2589–95.
Daurat A, Roger C, Gris J, Daurat G, Feissel M, Le Manach Y, et al. Apheresis platelets are more frequently associated with adverse reactions than pooled platelets both in recipients and in donors: a study from French hemovigilance data. Transfusion. 2016 Jun;56(6):1295–303.
Tiwari AK, Aggarwal G, Dara RC, Arora D, Srivastava K, Raina V. Post-donation telephonic interview of blood donors providing an insight into delayed adverse reactions: first attempt in India. Transfus Apheresis Sci. 2017 Apr;56(2):141–6.
Orru’ S, Poetzsch K, Hoffelner M, Heiden M, Funk M, B, Keller-Stanislawski B, Oberle D: Blood Donation-Related Adverse Reactions: Results of an Online Survey among Donors in Germany (2018). Transfus Med Hemother 2021;48:272-283. doi: 10.1159/000516049
Expert comments for publication:
This is an observational study that followed donors between 24 hours and 2 weeks after collection and concludes that delayed adverse reactions are more common in platelet donors compared to immediate adverse reactions. It is likely that the donors have a bias when reporting these reactions, especially the systemic ones as inputability may not be correctly assessed and the symptoms may be due to unrelated issues. Delayed adverse reactions were observed in 19.2% of platelet pheresis donors, compared to 5.46% of immediate adverse reactions; localized reactions (bruises, sore arm) were more common at 16.01% compared to systemic reactions (vasovagal reactions, fatigue) at 3.2%; donor adverse reactions were reported by 6.96% of first-time donors compared to only 1.6% of repeat donors. Some of the factors contributing to the systemic reactions are smaller body weight and lower platelet count.
The reported incidence of this particular study is higher compared to other studies, most likely due to the fact that donors were directly called opposed to the usual self-reporting advised by blood centers, which leads to reporting of even minor reactions.