Status:
Ready to upload
Record number:
2194
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Angiomyolipoma is considered a benign lesion that only rarely exhibits malignant characteristics, and is not specifically dealt with separately in current recommendations.
Time to detection:
Not relevant
Alerting signals, symptoms, evidence of occurrence:
Not relevant
Demonstration of imputability or root cause:
In this systematic review, donors were known to have angiomyolipoma prior to transplant. In some cases it was resected, in other cases it was not.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Suggest new keywords:
Malignancy
Review article
Kidney transplant
Angiomyolipoma
Therapy discussed
Reference attachment:
Suggest references:
Anton DG, Kovvuru K, Kanduri SR, Aeddula NR, Bathini T, Thongprayoon C, Kaewput W, Wijarnpreecha K, Watthanasuntorn K, Salim SA, Matemavi P, Vaitla P, Rivera FC, Cheungpasitporn W. Use and outcomes of kidneys from donors with renal angiomyolipoma: A systematic review. Urol Ann. 2021 Jan-Mar;13(1):67-72. doi: 10.4103/UA.UA_14_20. Epub 2021 Jan 19. PMID: 33897168; PMCID: PMC8052899.
Note:
upload MN 5/8/22
First review MN 4/28/24
Expert comments for publication:
This systematic review (updated to October 2019) documents 14 studies that describe 16 patients who received kidneys from donors with angiomyolipoma. 65% (n=9) of patients had ex vivo resection, 18% (n=3) no resection, and 17% in vivo resection (n=2) or not reported (n=1).
In those who did not have resection, the lesion size remained stable and none had malignant transformation. No donors with angiomyolipoma developed end stage renal disease.
It is important to note that none of the donors had angiomyolipoma associated with tuberous sclerosis complex or with lymphangiomyoleiomatosis (in 9 patients the tuberous sclerosis complex status was not reported).
The authors concluded that their findings support the safety of these kidneys for transplant. However, we also note the small numbers of reported cases.
The article also contains a general discussion of angiomyolipoma, including current therapy and associations, outside of the context of transplantation