Status:
Ready to upload
Record number:
2183
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Donor transmitted cancers are reported at a rate of 3-6 cases per 10,000 solid organ transplants.
Time to detection:
Most occur within the first 2 posttransplant years, although occasional examples occur outside of this time period.
Alerting signals, symptoms, evidence of occurrence:
Not applicable
Demonstration of imputability or root cause:
Not applicable
Imputability grade:
Not Assessable
Groups audience:
Keywords:
Suggest new keywords:
Malignancy
Review article
Deceased donor
Living donor
Liver transplant
Breast Cancer
Breast cancer, other or type not specified
CNS tumor, other or type not specified
Central nervous system cancer
Large bowel adenocarcinoma
Renal cell carcinoma
Lung cancer, type not specified
Prostate adenocarcinoma
Therapy discussed
Reference attachment:
Suggest references:
Domínguez-Gil B, Moench K, Watson C, Serrano MT, Hibi T, Asencio JM, Van Rosmalen M, Detry O, Heimbach J, Durand F. Prevention and Management of Donor-transmitted Cancer After Liver Transplantation: Guidelines From the ILTS-SETH Consensus Conference. Transplantation. 2022 Jan 1;106(1):e12-e29. doi: 10.1097/TP.0000000000003995. PMID: 34905759.
Note:
uploaded MN 5/8/22
first review MN 5.4.24
second review CLFF 5/20/24: Note the manuscript does not correctly reflect the use of donors with primary intracranial tumours WHO class 4: It is high risk and not unacceptable.
Expert comments for publication:
Note: An open source version of this article is available at https://orbi.uliege.be/handle/2268/266113.
This report from the International Liver Transplant Society-Spanish Society of Liver Transplantation Consensus Conference working group provides expert recommendations dealing with transmission of donor cancer, particularly in the case of liver transplantation. However, the recommendations are broadly applicable for all organ transplants and this summary is recommended as a good review of state of the art of this area as of 2022.
The paper includes 50 recommendations rated on strength of recommendation (weak to strong) and quality of evidence (low due to the nature of the subject). Topics include steps to minimize the occurrence of donor transmitted cancer (11 recommendations), risks of transmission of different cancer types (24 recommendations following Council of Europe guidelines and specifically mentioning in situ carcinoma, breast cancer, colorectal cancer, CNS neoplasia, lung, prostate, and renal cell cancer), management of transplant patients with donor-transmitted cancer (9 recommendations), special considerations for living liver donors (4 recommendations), and topics related to informing liver transplant candidates and establishing systems to more accurately assess the epidemiology of donor transmitted cancer (2 recommendations).
Recommended laboratory and radiologic tests are placed into context, and a summary of current national and international systems to assess donor cancer transmission risk is provided.
It is not possible to elaborate on all of the recommendations provided in this brief summary. However, this is a good reference for both an overview of, and for specific information related to, transmission of donor cancer by transplantation.