Case report: Melanoma transmitted by ocular limbal stem cell transplant (2017)

Most recent risk assessment for melanoma (Council of Europe, 2022): Due to the very aggressive behaviour of this tumour, it is considered an unacceptable risk for organ donation. Malignant melanoma in the donor history: Due to the lack of exhaustive data, transplanting organs from donors with treated malignant melanoma must still be considered to be associated with a high transmission risk. If precise donor data about staging, therapy, follow-up, and recurrence-free survival are available, and evaluation by the dermato-oncologist concludes there is a low probability of recurrence and metastasis, organ donation might be considered for selected recipients. Note: In addition to the Council of Europe recommendations, the Eye Bank Association of America excludes potential donors with any history of melanoma from donating keratolimbal tissue (guidelines available at https://restoresight.org/wp-content/uploads/2019/11/Med-Standards-October-10-2019.pdf). The European Eye Bank Association had excluded such donors prior to this case report (guidelines available at https://www.eeba.eu/files/pdf/EEBA%20Minimum%20Medical%20Standards%20Revision%205%20Final.pdf).